2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P992108
    Efadirelaxin alfa 3061442-66-5 98%
    Efadirelaxin alfa (RELAX10) is a highly selective agonist of relaxin/insulin-like family peptide receptor RXFP1. After subcutaneous administration in animal experiments, Efadirelaxin alfa exhibits a significantly prolonged terminal half-life (7 days in mice, 3.75 days in rats), and shows no activity against related receptors such as RXFP2 and RXFP3. Efadirelaxin alfa has significant anti-cardiac hypertrophy and anti-fibrotic effects. Efadirelaxin alfa effectively attenuates and reverses cardiac hypertrophy and collagen deposition by regulating the TGF-β1/Smad2 and AKT/eNOS signaling pathways. Efadirelaxin alfa improves cardiac systolic function without causing fluctuations in blood pressure or heart rate, demonstrating favorable safety. Efadirelaxin alfa is currently mainly used in studies related to heart failure.
    Efadirelaxin alfa
  • HY-RS29453
    Ctnna1 Rat Pre-designed siRNA Set A 98%
    Ctnna1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ctnna1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Ctnna1 Rat Pre-designed siRNA Set A
  • HY-U00013R
    Nitroflurbiprofen (Standard) 158836-71-6 98%
    Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.
    Nitroflurbiprofen (Standard)
  • HY-U00074R
    Rentiapril racemate (Standard) 72679-47-1 98%
    Rentiapril racemate (SA-446 racemate) is the racemate of Rentiapril. Rentiapril is an angiotensin converting enzyme (ACE) inhibitor.
    Rentiapril racemate (Standard)
  • HY-U00134R
    Benzcyclane (Standard) 2179-37-5 98%
    Benzcyclane (Standard) is the analytical standard of Benzcyclane (HY-U00134). This product is intended for research and analytical applications. Benzcyclane (Bencyclane; Benzcyclan) is a serotonin receptor antagonist and a cerebral/peripheral vasodilator. Benzcyclane exerts atypical serotonin antagonistic effects in rabbit superior mesenteric arteries. Benzcyclane relaxes high K+-induced contractions in rabbit basilar arteries and superior mesenteric arteries, and selectively inhibits sympathetic nerve stimulation-induced contractions in rabbit pulmonary arteries. Benzcyclane exerts non-competitive norepinephrine antagonistic effects in rabbit superior mesenteric arteries, and slightly reduces the maximum contractile response induced by histamine. Benzcyclane relaxes smooth muscles, induces transient hypotension, inhibits thrombosis, and accelerates blood fibrinolytic activity. Benzcyclane increases cerebral glucose content/uptake, enhances hypoxia tolerance in mice, and increases cerebral blood supply in dogs. Benzcyclane is applicable to studies related to cerebral vascular circulation.
    Benzcyclane (Standard)
  • HY-U00151A
    Dopropidil hydrochloride 117241-47-1 98%
    Dopropidil hydrochloride is a novel anti-anginal calcium ion modulating agent, possessing intracellular calcium antagonist activity and anti-ischemic effects in several predictive animal models.
    Dopropidil hydrochloride
  • HY-U00175R
    Pamicogrel (Standard) 101001-34-7 98%
    Pamicogrel (KBT3022) is a cyclooxygenase (COX) inhibitor.
    Pamicogrel (Standard)
  • HY-U00212R
    Aranidipine (Standard) 86780-90-7 98%
    Aranidipine (Standard) is the analytical standard of Aranidipine. This product is intended for research and analytical applications. Aranidipine (MPC1304) is a Ca2+ channel antagonist with potent and long-lasting antihypertensive effects.
    Aranidipine (Standard)
  • HY-W010143
    (R,S)-Norcotinine 17708-87-1 98%
    (R,S)-Norcotinine ((Rac)-Norcotinine) is the racemic mixture of Norcotinine. (R,S)-Norcotinine is a biomarker of secondhand smoke exposure and is associated with the toxic mechanisms of secondhand smoke on cardiovascular development.
    (R,S)-Norcotinine
  • HY-W015593
    Methylhexanamine hydrochloride 13803-74-2 98%
    Methylhexanamine hydrochloride is an aliphatic amine and a vasoconstrictor that can be administered by inhalation to the nasal mucosa to exert its effect as a nasal decongestant.
    Methylhexanamine hydrochloride
  • HY-W092067
    6-Hydroxyisatin 116569-08-5 98%
    6-Hydroxyisatin is an atrial natriuretic peptide receptor (ANP receptor) inhibitor. 6-Hydroxyisatin exhibits inhibitory activity against ANP-stimulated particulate guanylyl cyclase activity in rat brain cell membranes.
    6-Hydroxyisatin
  • HY-W099725
    Sarmentine 78910-33-5 99.06%
    Sarmentine is a broad-spectrum contact herbicide and PSII inhibitor, with an IC50 of 3.0 μM and a Ki of 1.5 μM against spinach, an IC50 of 1.72 μM against wild-type Amaranthus retroflexus, and an IC50 of 0.97 μM against triazine-resistant Amaranthus retroflexus. Sarmentine competitively binds to the QB binding site of plastoquinone on PSII, thereby blocking photosynthetic electron transport. Sarmentine inhibits enoyl-ACP reductase in Arabidopsis thaliana by targeting the early fatty acid synthesis process, with an IC50 of 18.3 μM. Sarmentine induces light-independent loss of plasma membrane integrity and electrolyte leakage. Sarmentine also exhibits antiplasmodial, antimycobacterial, antituberculous, and antiplatelet aggregation activities.
    Sarmentine
  • HY-W103372
    Vasorelaxant agent-2 53242-88-9 98%
    Vasorelaxant agent-2 (Compound 8h) targets α1A-adrenergic receptor with an affinity of pD2=5.4. Vasorelaxant agent-2 exhibits vasodilator activity in rats aortic rings with an EC50 of 0.79 μM.
    Vasorelaxant agent-2
  • HY-W197533
    3-Hydroxymethyl-β-carboline 65474-79-5 98%
    3-Hydroxymethyl-β-carboline is a Benzodiazepine antagonist with a Ki value of ~1470 nM. 3-Hydroxymethyl-β-carboline reverses Flurazepam-induced sleep, cerebrovascular and cerebral metabolic inhibition, and also partially reverses Flurazepam-induced decreases in blood pressure and heart rate. 3-Hydroxymethyl-β-carboline disrupts the anticonvulsant and anxiolytic effects of Diazepam in male mice. 3-Hydroxymethyl-β-carboline has no effect on sodium-dependent high-affinity choline uptake in rat cortical or hippocampal synaptosomes.
    3-Hydroxymethyl-β-carboline
  • HY-W250153
    Adenosine 3'-phosphate 5'-phosphosulfate lithium 109434-21-1 98%
    Adenosine 3'-phosphate 5'-phosphosulfate lithium, an adenine nucleotide derivative, is a selective P2Y1 antagonist with no effect on P2Y2, P2Y4, or P2Y6 receptors. Adenosine 3'-phosphate 5'-phosphosulfate lithium can competitive inhibit ADP-induced platelet aggregation, as well as the ability of ADP to cause shape change and increases in Ca2+ in platelets, but had no effect on the inhibition of stimulated adenylate cyclase by ADP. Adenosine 3'-phosphate 5'-phosphosulfate lithium is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate lithium can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group.
    Adenosine 3'-phosphate 5'-phosphosulfate lithium
  • HY-W273690
    Pentifylline 1028-33-7 99.23%
    Pentifylline (1-Hexyltheobromine; Hexyltheobromine), PTX (HY-B0715) precursor compound, is a vasodilator. Pentifylline decreases procollagen levels and inhibits collagen production. Pentifylline reduces functional nuclear NF-1 to suppress procollagen gene transcription.
    Pentifylline
  • HY-W288642
    6-(3,4,5-Trimethoxybenzamido)hexanoic acid 21434-91-3 98%
    6-(3,4,5-Trimethoxybenzamido)hexanoic acid is an antiarrythmic agent.
    6-(3,4,5-Trimethoxybenzamido)hexanoic acid
  • HY-W319939
    3-(4-Hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one 104236-73-9 98%
    3-(4-Hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one (Compound 5) is a selective lipid peroxidation inhibitor. 3-(4-Hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one is promising for research of diseases related to oxidative stress, such as cardiovascular diseases and neurodegenerative diseases.
    3-(4-Hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one
  • HY-W410706
    1-Salicylate glucuronide 7695-70-7 98%
    1-Salicylate glucuronide is a metabolite of Salicylic acid (HY-B0167) and Aspirin (HY-14654).
    1-Salicylate glucuronide
  • HY-W416440
    Esmolol acid hydrochloride 83356-60-9 98%
    Esmolol acid (ASL-8123) hydrochloride is a weak β-adrenergic receptor antagonist. Esmolol acid hydrochloride inhibits the heart rate and diastolic blood pressure response induced by Isoproterenol (HY-B0468) in a dose-dependent manner and can be used in studies of renal failure.
    Esmolol acid hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity